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The mutations reported from Kallikrein are listed below: Click on the highlighted residues for further information on mutation. MILFKQATYFISLFATVSCGCLTQLYENAFFRGGDVASMYTPNAQYCQMRCTFHPRCLLF SFLPASSINDMEKRFGCFLKDSVTGTLPKVHRTGAVSGHSLKQCGHQISACHRDIYKGVD MRGVNFNVSKVSSVEECQKRCTNNIRCQFFSYATQTFHKAEYRNNCLLKYSPGGTPTAIK VLSNVESGFSLKPCALSEIGCHMNIFQHLAFSDVDVARVLTPDAFVCRTICTYHPNCLFF TFYTNVWKIESQRNVCLLKTSESGTPSSSTPQENTISGYSLLTCKRTLPEPCHSKIYPGV DFGGEELNVTFVKGVNVCQETCTKMIRCQFFTYSLLPEDCKEEKCKCFLRLSMDGSPTRI AYGTQGSSGYSLRLCNTGDNSVCTTKTSTRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCG GSLIGHQWVLTAAHCFDGLPLQDVWRIYSGILNLSDITKDTPFSQIKEIIIHQNYKVSEG NHDIALIKLQAPLNYTEFQKPICLPSKGDTSTIYTNCWVTGWGFSKEKGEIQNILQKVNI PLVTNEECQKRYQDYKITQRMVCAGYKEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGE GCARREQPGVYTKVAEYMDWILEKTQSSDGKAQMQSPA Missense Position* Wild type Mutant Domain PMID 123 Gly Arg Peptidase S1 17598838 143 Asn Ser Peptidase S1 17598838 420 Gly Glu   12871337, 19713668 548 Cys Tyr   20829681, 20510102, 19923982, 20860169, 577 Asp Glu   20301226 Insertion Mutation Codon Exon/Intron Domain PMID  insT  149  Exon 5    20301226 Nonsense Mutation* Codon Exon/Intron Domain PMID  Trp518X        21415712  Trp402X    Exon 11  Peptidase S1  14652634 * The positions are based on the protein sequence inclusive of the signal peptide if present.

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