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The mutations reported from Plasminogen are listed below: Click on the highlighted residues for further information on mutation. MEHKEVVLLLLLFLKSGQGEPLDDYVNTQGASLFSVTKKQLGAGSIEECAAKCEEDEEFT CRAFQYHSKEQQCVIMAENRKSSIIIRMRDVVLFEKKVYLSECKTGNGKNYRGTMSKTKN GITCQKWSSTSPHRPRFSPATHPSEGLEENYCRNPDNDPQGPWCYTTDPEKRYDYCDILE CEEECMHCSGENYDGKISKTMSGLECQAWDSQSPHAHGYIPSKFPNKNLKKNYCRNPDRE LRPWCFTTDPNKRWELCDIPRCTTPPPSSGPTYQCLKGTGENYRGNVAVTVSGHTCQHWS AQTPHTHNRTPENFPCKNLDENYCRNPDGKRAPWCHTTNSQVRWEYCKIPSCDSSPVSTE QLAPTAPPELTPVVQDCYHGDGQSYRGTSSTTTTGKKCQSWSSMTPHRHQKTPENYPNAG LTMNYCRNPDADKGPWCFTTDPSVRWEYCNLKKCSGTEASVVAPPPVVLLPDVETPSEED CMFGNGKGYRGKRATTVTGTPCQDWAAQEPHRHSIFTPETNPRAGLEKNYCRNPDGDVGG PWCYTTNPRKLYDYCDVPQCAAPSFDCGKPQVEPKKCPGRVVGGCVAHPHSWPWQVSLRT RFGMHFCGGTLISPEWVLTAAHCLEKSPRPSSYKVILGAHQEVNLEPHVQEIEVSRLFLE PTRKDIALLKLSSPAVITDKVIPACLPSPNYVVADRTECFITGWGETQGTFGAGLLKEAQ LPVIENKVCNRYEFLNGRVQSTELCAGHLAGGTDSCQGDSGGPLVCFEKDKYILQGVTSW GLGCARPNKPGVYVRVSRFVTWIEGVMRNN Missense Position* Wild type Mutant Domain PMID 38 Lys Glu PAN 16849641, 11424676, 10233898, 12945885, 17179833, 12876630 147 Leu Pro Kringle 1 10233898 153 Arg Lys Kringle 1 16849641, 11424676 185 Cys Tyr Kringle 2 21174000 235 Arg His Kringle 2 16849641, 10233898, 9242524 283 Tyr Ser Kringle 3 21174000 304 Pro Ala Kringle 3 16849641 304 Pro Thr Kringle 3 16849641 532 Arg His Kringle 5 10233898 591 Ser Pro Peptidase S1 8392398 616 Trp Cys Peptidase S1 9242524 620 Ala Thr Peptidase S1 1427790 751 Gly Arg Peptidase S1 9858247 795 Arg His Peptidase S1 16849641 Splice site Mutation Codon Exon/Intron Domain PMID  IVS10-7T/G        21174000 * The positions are based on the protein sequence inclusive of the signal peptide if present.

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