Result

  Antithrombin III

Source	Ovis aries (sheep)
Taxonomy	Ovis aries Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis.
Keywords	Blood coagulation; Disulfide bond; Glycoprotein; Heparin-binding; Phosphoprotein; Protease inhibitor; Secreted; Serine protease inhibitor; Signal.
Details Function: Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin. Post-translational modification: Phosphorylation sites are present in the extracelllular medium (By similarity). Similarity: Belongs to the serpin family. Subcellular location: Secreted, extracellular space. Tissue specificity: Plasma. Sequence length: 465 AA.
Sequence MISNGIGTVTTGKRSMCLFPLLLIGLWGCVTCHRSPVEDICTAKPRDIPVNPMCIYRSPE KKATEGEGSEQKIPGATNRRVWELSKANSHFATAFYQHLADSKNNNDNIFLSPLSISTAF AMTKLGACNNTLKQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSELVSANRLF GDKSITFNETYQDISEVVYGAKLQPLDFKGNAEQSRLTINQWISNKTEGRITDVIPPQAI DEFTVLVLVNTIYFKGLWKSKFSPENTKKELFYKADGESCSVPMMYQEGKFRYRRVAEGT QVLELPFKGDDITMVLILPKLEKPLAKVERELTPDMLQEWLDELTETLLVVHMPHFRIED SFSVKEQLQDMGLEDLFSPEKSRLPGIVAEGRNDLYVSDAFHKAFLEVNEEGSEAAASTV ISIAGRSLNLNRVTFQANRPFLVLIREVALNTIIFMGRVANPCVN
Accession Number	P32262
PubMed ID	1482684
CTD DB	443407
GeneID DB	443407
GO DB	0005615, 0008201, 0004867, 0007596
InterPro DB	IPR000215, IPR015555
NCBI	X68287, CAA48347
OMIM	105200, 134820, 202400, 134830, 202400, 134850, 202400, 176930, 601367, 134390, 188055, 227400, 600880, 601367, 612309, 227500, 134500, 306700, 300746, 306900, 227600, 176860, 188050, 612283, 612304, 176880, 612336, 264900, 612416, 234000, 610618, 610619, 229000, 612423, 107300, 188050
Pfam	PF00079
PROSITE DB	PS00284
SMART DB	SM00093
UniGene	Oar.420